Dr Michael Holmes
|Tel||+44 (0)1865 743644|
BSc(Hons) MBBS MSc(Epidemiology) PhD MRCP
Senior Clinical Research Fellow in Cardiovascular Medicine
- Clinical Trial Service Unit and Epidemiological Studies Unit
Michael Holmes studied Medicine at University of St Andrews and University College London, graduating in 2005. Working in the NHS as a hospital physician, he held NIHR clinical academic posts including academic foundation year and an academic clinical fellowship in Clinical Pharmacology and Therapeutics/General Internal Medicine. Michael then undertook a Masters in Epidemiology at London School of Hygiene and Tropical Medicine and completed a PhD in Genetic Epidemiology at University College London. Following his PhD, he was Assistant Professor at University of Pennsylvania, Philadelphia, USA, where he investigated genetic determinants of clinical outcomes following organ transplantation.
Michael is a Senior Clinical Research Fellow in Cardiovascular Medicine at CTSU. He is working within the China Kadoorie Biobank (CKB) to investigate causal risk factors underpinning cardiovascular disease and cancer subtypes. Michael's expertise lies in using genetic variants to disentangle causality from confounding with the aim of improving understanding of disease aetiology and identifying novel therapeutic targets for disease prevention.
Problems in interpreting and using GWAS of conditional phenotypes illustrated by 'alcohol GWAS'
Holmes MV. and Davey Smith G., (2018), Molecular Psychiatry, 1 - 2
Lipids, Lipoproteins, and Metabolites and Risk of Myocardial Infarction and Stroke.
Holmes MV. et al, (2018), J Am Coll Cardiol, 71, 620 - 632
Challenges in Interpreting Multivariable Mendelian Randomization: Might "Good Cholesterol" Be Good After All?
Holmes MV. and Davey Smith G., (2018), Am J Kidney Dis, 71, 149 - 153
Associations of General and Central Adiposity With Incident Diabetes in Chinese Men and Women.
Bragg F. et al, (2018), Diabetes care
Association of CETP Gene Variants With Risk for Vascular and Nonvascular Diseases Among Chinese Adults
Millwood IY., (2018), JAMA Cardiology