Associate Professor Michael Holmes
BSc(Hons) MBBS MSc(Epidemiology) PhD MRCP
- Clinical Trial Service Unit and Epidemiological Studies Unit
Michael Holmes studied Medicine at University of St Andrews and University College London, graduating in 2005. Working in the NHS as a hospital physician, he held NIHR clinical academic posts including academic foundation year and an academic clinical fellowship in Clinical Pharmacology and Therapeutics/General Internal Medicine. Michael then undertook a Masters in Epidemiology at London School of Hygiene and Tropical Medicine and completed a PhD in Genetic Epidemiology at University College London. Following his PhD, he was Assistant Professor at University of Pennsylvania, Philadelphia, USA, where he investigated genetic determinants of clinical outcomes following organ transplantation.
Michael is a Senior Clinical Research Fellow in Cardiovascular Medicine at CTSU. He is working within the China Kadoorie Biobank (CKB) to investigate causal risk factors underpinning cardiovascular disease and cancer subtypes. Michael's expertise lies in using genetic variants to disentangle causality from confounding with the aim of improving understanding of disease aetiology and identifying novel therapeutic targets for disease prevention.
A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome.
Wiberg A. et al, (2019), Nat Commun, 10
Cholesteryl Ester Transfer Protein Inhibition for Preventing Cardiovascular Events: JACC Review Topic of the Week.
Armitage J. et al, (2019), J Am Coll Cardiol, 73, 477 - 487
What is 'LDL cholesterol'?
Holmes MV. and Ala-Korpela M., (2019), Nat Rev Cardiol
Can Mendelian Randomization Shift into Reverse Gear?
Holmes MV. and Smith GD., (2019), Clin Chem
Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics.
Tynkkynen T. et al, (2019), Int J Epidemiol