Associate Professor Michael Holmes
BSc(Hons) MBBS MSc(Epidemiology) PhD MRCP
- Clinical Trial Service Unit and Epidemiological Studies Unit
Michael Holmes studied Medicine at University of St Andrews and University College London, graduating in 2005. Working in the NHS as a hospital physician, he held NIHR clinical academic posts including academic foundation year and an academic clinical fellowship in Clinical Pharmacology and Therapeutics/General Internal Medicine. Michael then undertook a Masters in Epidemiology at London School of Hygiene and Tropical Medicine and completed a PhD in Genetic Epidemiology at University College London. Following his PhD, he was Assistant Professor at University of Pennsylvania, Philadelphia, USA, where he investigated genetic determinants of clinical outcomes following organ transplantation.
Michael is a Senior Clinical Research Fellow in Cardiovascular Medicine at CTSU. He is working within the China Kadoorie Biobank (CKB) to investigate causal risk factors underpinning cardiovascular disease and cancer subtypes. Michael's expertise lies in using genetic variants to disentangle causality from confounding with the aim of improving understanding of disease aetiology and identifying novel therapeutic targets for disease prevention.
Using human genetics to guide the repurposing of medicines.
Bovijn J. et al, (2020), Int J Epidemiol
Apolipoprotein A-I concentrations and risk of coronary artery disease: A Mendelian randomization study.
Karjalainen MK. et al, (2020), Atherosclerosis
Socioeconomic status in relation to risks of major gastrointestinal cancers in Chinese adults: a prospective study of 0.5 million people.
Pang Y. et al, (2020), Cancer Epidemiol Biomarkers Prev
Colocalization highlights genes in hypothalamic–pituitary–gonadal axis as potentially mediating polycystic ovary syndrome risk
Censin J. et al, (2020)
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
Shah S. et al, (2020), Nat Commun, 11